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Low-dosebupropion given in the morning in combination with anSSRI given at night is often an effective and well-toler-ated treatment for elders with dementia and depression.Mirtazapine has a particular niche in the treatment ofelders with poor appetite and insomnia. Thecomplete mix of all risk factors to which an individual isexposed has been recently defined as the exposome.
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They are remarkably safe in low doses usedover short periods.
The higher protein load of that preparation, compared to that of thecurrently available toxin (1997 Botox®), may have made it more antigenic.